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After performing the integration analysis between miRNA and gene expression values with the mirnaIntegration() function, the results are stored in the integration slot of a MirnaExperiment object and can be explored with this function.

Usage

integration(object, param = FALSE)

Arguments

object

A MirnaExperiment object containing miRNA and gene data

param

Logical, whether to return the complete list object with the parameters used, or just the results stored in data. Default is FALSE

Value

If param is FALSE, then this functions returns a data.frame object containing the results of the integration analysis. Otherwise, a list

object including the parameters used for the analysis will be returned.

Author

Jacopo Ronchi, jacopo.ronchi@unimib.it

Examples

# load example MirnaExperiment object
obj <- loadExamples()

# visualize the results of correlation analysis
res <- integration(obj)
res
#>                             microRNA   Target microRNA.Direction
#> hsa.miR.1179.7          hsa-miR-1179    ITGA6      downregulated
#> hsa.miR.1179.10         hsa-miR-1179    RBMS2      downregulated
#> hsa.miR.1179.12         hsa-miR-1179   SPIRE1      downregulated
#> hsa.miR.1179.14         hsa-miR-1179     TAF5      downregulated
#> hsa.miR.1275.1          hsa-miR-1275    CCND2      downregulated
#> hsa.miR.1275.2          hsa-miR-1275     CD44      downregulated
#> hsa.miR.1275.7          hsa-miR-1275    ITGA3      downregulated
#> hsa.miR.1275.8          hsa-miR-1275    LLGL1      downregulated
#> hsa.miR.1275.9          hsa-miR-1275      MDK      downregulated
#> hsa.miR.1275.10         hsa-miR-1275     NAB2      downregulated
#> hsa.miR.1275.11         hsa-miR-1275     NUMB      downregulated
#> hsa.miR.1275.14         hsa-miR-1275     THRA      downregulated
#> hsa.miR.1275.16         hsa-miR-1275    TNNI1      downregulated
#> hsa.miR.138.1.3p    hsa-miR-138-1-3p   CCDC18      downregulated
#> hsa.miR.138.1.3p.1  hsa-miR-138-1-3p    CCND2      downregulated
#> hsa.miR.138.1.3p.8  hsa-miR-138-1-3p   LRP2BP      downregulated
#> hsa.miR.138.1.3p.11 hsa-miR-138-1-3p    TNNI1      downregulated
#> hsa.miR.138.1.3p.14 hsa-miR-138-1-3p   ZNF276      downregulated
#> hsa.miR.138.5p.1      hsa-miR-138-5p    ATG9B      downregulated
#> hsa.miR.138.5p.2      hsa-miR-138-5p     CD44      downregulated
#> hsa.miR.138.5p.3      hsa-miR-138-5p    CLCN2      downregulated
#> hsa.miR.138.5p.7      hsa-miR-138-5p     DTX4      downregulated
#> hsa.miR.138.5p.9      hsa-miR-138-5p     OGG1      downregulated
#> hsa.miR.138.5p.11     hsa-miR-138-5p    RBBP4      downregulated
#> hsa.miR.138.5p.14     hsa-miR-138-5p   VPS37A      downregulated
#> hsa.miR.139.5p.3      hsa-miR-139-5p    CCND2      downregulated
#> hsa.miR.139.5p.5      hsa-miR-139-5p     ECE1      downregulated
#> hsa.miR.139.5p.6      hsa-miR-139-5p      FN1      downregulated
#> hsa.miR.139.5p.8      hsa-miR-139-5p    ITGA3      downregulated
#> hsa.miR.139.5p.15     hsa-miR-139-5p   SPIRE1      downregulated
#> hsa.miR.139.5p.17     hsa-miR-139-5p   TSPAN3      downregulated
#> hsa.miR.144.3p.4      hsa-miR-144-3p   DCBLD2      downregulated
#> hsa.miR.144.3p.26     hsa-miR-144-3p   TSPAN3      downregulated
#> hsa.miR.144.5p.7      hsa-miR-144-5p     TAF5      downregulated
#> hsa.miR.146b.3p.1    hsa-miR-146b-3p     BCL2        upregulated
#> hsa.miR.146b.3p.9    hsa-miR-146b-3p    JMJD4        upregulated
#> hsa.miR.146b.3p.10   hsa-miR-146b-3p    LIMD1        upregulated
#> hsa.miR.146b.3p.11   hsa-miR-146b-3p   MED12L        upregulated
#> hsa.miR.146b.3p.13   hsa-miR-146b-3p     PAX8        upregulated
#> hsa.miR.146b.3p.15   hsa-miR-146b-3p   SORBS2        upregulated
#> hsa.miR.146b.3p.16   hsa-miR-146b-3p   SPTBN1        upregulated
#> hsa.miR.146b.3p.17   hsa-miR-146b-3p    TAF9B        upregulated
#> hsa.miR.146b.3p.22   hsa-miR-146b-3p  ZFP36L2        upregulated
#> hsa.miR.146b.3p.23   hsa-miR-146b-3p  ZMYND11        upregulated
#> hsa.miR.146b.5p      hsa-miR-146b-5p  ANKRD28        upregulated
#> hsa.miR.146b.5p.2    hsa-miR-146b-5p     CD24        upregulated
#> hsa.miR.146b.5p.3    hsa-miR-146b-5p     CUL5        upregulated
#> hsa.miR.146b.5p.4    hsa-miR-146b-5p   CYBRD1        upregulated
#> hsa.miR.146b.5p.5    hsa-miR-146b-5p     DIO2        upregulated
#> hsa.miR.146b.5p.6    hsa-miR-146b-5p     EGR1        upregulated
#> hsa.miR.146b.5p.7    hsa-miR-146b-5p    FBXL3        upregulated
#> hsa.miR.146b.5p.8    hsa-miR-146b-5p     FHL1        upregulated
#> hsa.miR.146b.5p.10   hsa-miR-146b-5p    HYOU1        upregulated
#> hsa.miR.146b.5p.15   hsa-miR-146b-5p     PAX8        upregulated
#> hsa.miR.146b.5p.16   hsa-miR-146b-5p    SMAD2        upregulated
#> hsa.miR.146b.5p.17   hsa-miR-146b-5p   SPTBN1        upregulated
#> hsa.miR.146b.5p.18   hsa-miR-146b-5p    TAF9B        upregulated
#> hsa.miR.182.5p        hsa-miR-182-5p     BCL2        upregulated
#> hsa.miR.182.5p.2      hsa-miR-182-5p   CITED2        upregulated
#> hsa.miR.182.5p.3      hsa-miR-182-5p     CUL5        upregulated
#> hsa.miR.182.5p.4      hsa-miR-182-5p     FHL1        upregulated
#> hsa.miR.182.5p.8      hsa-miR-182-5p     SDC2        upregulated
#> hsa.miR.182.5p.10     hsa-miR-182-5p   SPTBN1        upregulated
#> hsa.miR.182.5p.12     hsa-miR-182-5p     TOB1        upregulated
#> hsa.miR.183.5p.6      hsa-miR-183-5p      EZR        upregulated
#> hsa.miR.183.5p.7      hsa-miR-183-5p   HNRNPM        upregulated
#> hsa.miR.183.5p.11     hsa-miR-183-5p   MED12L        upregulated
#> hsa.miR.204.5p.1      hsa-miR-204-5p    CCND2      downregulated
#> hsa.miR.204.5p.2      hsa-miR-204-5p     CD44      downregulated
#> hsa.miR.204.5p.3      hsa-miR-204-5p     DTX4      downregulated
#> hsa.miR.204.5p.8      hsa-miR-204-5p HLA-DRB5      downregulated
#> hsa.miR.204.5p.10     hsa-miR-204-5p  RHOBTB2      downregulated
#> hsa.miR.204.5p.11     hsa-miR-204-5p     SLA2      downregulated
#> hsa.miR.204.5p.13     hsa-miR-204-5p    STAT6      downregulated
#> hsa.miR.204.5p.14     hsa-miR-204-5p     TAF5      downregulated
#> hsa.miR.21.3p          hsa-miR-21-3p     CANX        upregulated
#> hsa.miR.21.3p.1        hsa-miR-21-3p     CUL5        upregulated
#> hsa.miR.21.3p.2        hsa-miR-21-3p     DIO2        upregulated
#> hsa.miR.21.3p.3        hsa-miR-21-3p     GJA1        upregulated
#> hsa.miR.21.3p.7        hsa-miR-21-3p     SDC2        upregulated
#> hsa.miR.21.3p.8        hsa-miR-21-3p  SMARCA2        upregulated
#> hsa.miR.21.5p          hsa-miR-21-5p    AIF1L        upregulated
#> hsa.miR.21.5p.1        hsa-miR-21-5p  ANKRD28        upregulated
#> hsa.miR.21.5p.3        hsa-miR-21-5p    APAF1        upregulated
#> hsa.miR.21.5p.4        hsa-miR-21-5p ARHGAP24        upregulated
#> hsa.miR.21.5p.5        hsa-miR-21-5p     BCL2        upregulated
#> hsa.miR.21.5p.6        hsa-miR-21-5p   CYBRD1        upregulated
#> hsa.miR.21.5p.8        hsa-miR-21-5p    MATN2        upregulated
#> hsa.miR.21.5p.10       hsa-miR-21-5p   MED12L        upregulated
#> hsa.miR.21.5p.15       hsa-miR-21-5p     TOB1        upregulated
#> hsa.miR.2110.1          hsa-miR-2110    AIF1L        upregulated
#> hsa.miR.2110.3          hsa-miR-2110   CYBRD1        upregulated
#> hsa.miR.2110.9          hsa-miR-2110   MED12L        upregulated
#> hsa.miR.2110.12         hsa-miR-2110    SMAD2        upregulated
#> hsa.miR.221.3p        hsa-miR-221-3p  ANKRD28        upregulated
#> hsa.miR.221.3p.2      hsa-miR-221-3p    APAF1        upregulated
#> hsa.miR.221.3p.3      hsa-miR-221-3p     BCL2        upregulated
#> hsa.miR.221.3p.6      hsa-miR-221-3p     CUL5        upregulated
#> hsa.miR.221.3p.17     hsa-miR-221-3p  SMARCA2        upregulated
#> hsa.miR.221.3p.18     hsa-miR-221-3p   SPTBN1        upregulated
#> hsa.miR.221.3p.21     hsa-miR-221-3p     URI1        upregulated
#> hsa.miR.221.5p        hsa-miR-221-5p  ANKRD28        upregulated
#> hsa.miR.221.5p.1      hsa-miR-221-5p    APAF1        upregulated
#> hsa.miR.221.5p.6      hsa-miR-221-5p      IYD        upregulated
#> hsa.miR.221.5p.7      hsa-miR-221-5p    LIMD1        upregulated
#> hsa.miR.221.5p.10     hsa-miR-221-5p     URI1        upregulated
#> hsa.miR.222.3p        hsa-miR-222-3p  ANKRD28        upregulated
#> hsa.miR.222.3p.2      hsa-miR-222-3p    APAF1        upregulated
#> hsa.miR.222.3p.4      hsa-miR-222-3p     BCL2        upregulated
#> hsa.miR.222.3p.5      hsa-miR-222-3p     CANX        upregulated
#> hsa.miR.222.3p.9      hsa-miR-222-3p      EZR        upregulated
#> hsa.miR.222.3p.11     hsa-miR-222-3p    GPBP1        upregulated
#> hsa.miR.222.3p.18     hsa-miR-222-3p  SMARCA2        upregulated
#> hsa.miR.222.3p.22     hsa-miR-222-3p     URI1        upregulated
#> hsa.miR.31.3p          hsa-miR-31-3p     CANX        upregulated
#> hsa.miR.31.3p.1        hsa-miR-31-3p   COL9A3        upregulated
#> hsa.miR.31.3p.2        hsa-miR-31-3p     CUL5        upregulated
#> hsa.miR.31.3p.3        hsa-miR-31-3p    LIMD1        upregulated
#> hsa.miR.31.3p.4        hsa-miR-31-3p   MED12L        upregulated
#> hsa.miR.31.3p.6        hsa-miR-31-3p  SLC26A7        upregulated
#> hsa.miR.31.3p.7        hsa-miR-31-3p    SMAD2        upregulated
#> hsa.miR.31.5p.2        hsa-miR-31-5p     CUL5        upregulated
#> hsa.miR.31.5p.5        hsa-miR-31-5p   GIGYF2        upregulated
#> hsa.miR.31.5p.6        hsa-miR-31-5p      JUN        upregulated
#> hsa.miR.31.5p.7        hsa-miR-31-5p     MICA        upregulated
#> hsa.miR.31.5p.10       hsa-miR-31-5p   SPTBN1        upregulated
#> hsa.miR.34a.5p        hsa-miR-34a-5p    APAF1        upregulated
#> hsa.miR.34a.5p.1      hsa-miR-34a-5p     BCL2        upregulated
#> hsa.miR.34a.5p.3      hsa-miR-34a-5p     CD24        upregulated
#> hsa.miR.34a.5p.7      hsa-miR-34a-5p   GIGYF2        upregulated
#> hsa.miR.34a.5p.9      hsa-miR-34a-5p    LIMD1        upregulated
#> hsa.miR.34a.5p.13     hsa-miR-34a-5p   SPTBN1        upregulated
#> hsa.miR.34a.5p.14     hsa-miR-34a-5p    SYNE2        upregulated
#> hsa.miR.34a.5p.18     hsa-miR-34a-5p  ZMYND11        upregulated
#> hsa.miR.3613.5p.3    hsa-miR-3613-5p   MED12L        upregulated
#> hsa.miR.3613.5p.4    hsa-miR-3613-5p   PAPSS2        upregulated
#> hsa.miR.3613.5p.5    hsa-miR-3613-5p  SLC26A4        upregulated
#> hsa.miR.3613.5p.6    hsa-miR-3613-5p  SLC26A7        upregulated
#> hsa.miR.3613.5p.7    hsa-miR-3613-5p    SYNE2        upregulated
#> hsa.miR.375.1            hsa-miR-375     BCL2        upregulated
#> hsa.miR.375.3            hsa-miR-375      DEK        upregulated
#> hsa.miR.451a.2          hsa-miR-451a    CCND2      downregulated
#> hsa.miR.451a.3          hsa-miR-451a   DCBLD2      downregulated
#> hsa.miR.451a.7          hsa-miR-451a   TNRC6C      downregulated
#> hsa.miR.486.3p.3      hsa-miR-486-3p    CCND2      downregulated
#> hsa.miR.486.3p.5      hsa-miR-486-3p    EFHD2      downregulated
#> hsa.miR.486.3p.9      hsa-miR-486-3p    LLGL1      downregulated
#> hsa.miR.486.5p        hsa-miR-486-5p   DCBLD2      downregulated
#> hsa.miR.486.5p.5      hsa-miR-486-5p    RBMS2      downregulated
#> hsa.miR.504.5p.6      hsa-miR-504-5p    LLGL1      downregulated
#> hsa.miR.504.5p.7      hsa-miR-504-5p    LUC7L      downregulated
#> hsa.miR.504.5p.9      hsa-miR-504-5p   MTHFD2      downregulated
#> hsa.miR.504.5p.10     hsa-miR-504-5p     NAB2      downregulated
#> hsa.miR.504.5p.11     hsa-miR-504-5p    TNNI1      downregulated
#> hsa.miR.551b.3p      hsa-miR-551b-3p    AIF1L        upregulated
#> hsa.miR.551b.3p.3    hsa-miR-551b-3p   GIGYF2        upregulated
#> hsa.miR.551b.3p.4    hsa-miR-551b-3p    GPBP1        upregulated
#> hsa.miR.551b.3p.8    hsa-miR-551b-3p      IYD        upregulated
#> hsa.miR.551b.3p.10   hsa-miR-551b-3p    NUPR1        upregulated
#> hsa.miR.551b.3p.12   hsa-miR-551b-3p     RYR2        upregulated
#> hsa.miR.551b.3p.13   hsa-miR-551b-3p  SMARCA2        upregulated
#> hsa.miR.551b.3p.14   hsa-miR-551b-3p    SMPD4        upregulated
#> hsa.miR.577              hsa-miR-577      AGK      downregulated
#> hsa.miR.577.4            hsa-miR-577     CD44      downregulated
#> hsa.miR.577.8            hsa-miR-577     LMO3      downregulated
#> hsa.miR.577.9            hsa-miR-577   LRP2BP      downregulated
#> hsa.miR.577.10           hsa-miR-577   MTHFD2      downregulated
#> hsa.miR.577.17           hsa-miR-577     WSB2      downregulated
#> hsa.miR.652.3p.4      hsa-miR-652-3p    CCND2      downregulated
#> hsa.miR.652.3p.6      hsa-miR-652-3p    EFHD2      downregulated
#> hsa.miR.652.3p.11     hsa-miR-652-3p    LLGL1      downregulated
#> hsa.miR.652.3p.12     hsa-miR-652-3p     LMO3      downregulated
#> hsa.miR.652.3p.13     hsa-miR-652-3p    MGST1      downregulated
#> hsa.miR.652.3p.18     hsa-miR-652-3p   VPS37A      downregulated
#> hsa.miR.652.3p.20     hsa-miR-652-3p  ZFP36L1      downregulated
#> hsa.miR.653.5p.1      hsa-miR-653-5p     BCL2        upregulated
#> hsa.miR.653.5p.3      hsa-miR-653-5p   CITED2        upregulated
#> hsa.miR.653.5p.6      hsa-miR-653-5p     DIO2        upregulated
#> hsa.miR.653.5p.10     hsa-miR-653-5p    HYOU1        upregulated
#> hsa.miR.653.5p.12     hsa-miR-653-5p      IYD        upregulated
#> hsa.miR.653.5p.15     hsa-miR-653-5p   NECAB1        upregulated
#> hsa.miR.653.5p.21     hsa-miR-653-5p    SMAD2        upregulated
#> hsa.miR.653.5p.22     hsa-miR-653-5p     URI1        upregulated
#> hsa.miR.6842.3p.4    hsa-miR-6842-3p    LIMD1        upregulated
#> hsa.miR.6842.3p.7    hsa-miR-6842-3p  SLC26A7        upregulated
#> hsa.miR.7.5p.6          hsa-miR-7-5p    CCND2      downregulated
#> hsa.miR.873.3p        hsa-miR-873-3p    CCND2      downregulated
#> hsa.miR.873.3p.1      hsa-miR-873-3p     CD44      downregulated
#> hsa.miR.873.3p.7      hsa-miR-873-3p    RBBP4      downregulated
#> hsa.miR.873.3p.10     hsa-miR-873-3p    SYTL4      downregulated
#> hsa.miR.873.3p.12     hsa-miR-873-3p   VPS37A      downregulated
#> hsa.miR.873.5p.1      hsa-miR-873-5p     DDR1      downregulated
#> hsa.miR.873.5p.7      hsa-miR-873-5p   NPEPPS      downregulated
#> hsa.miR.873.5p.11     hsa-miR-873-5p    RBMS2      downregulated
#> hsa.miR.874.3p.5      hsa-miR-874-3p    CCND2      downregulated
#> hsa.miR.874.3p.6      hsa-miR-874-3p     ECE1      downregulated
#> hsa.miR.874.3p.7      hsa-miR-874-3p     FZD4      downregulated
#> hsa.miR.874.3p.11     hsa-miR-874-3p  S100A13      downregulated
#> hsa.miR.874.3p.15     hsa-miR-874-3p     THRA      downregulated
#> hsa.miR.874.3p.16     hsa-miR-874-3p    TNNI1      downregulated
#> hsa.miR.874.3p.17     hsa-miR-874-3p   TNRC6C      downregulated
#> hsa.miR.9.5p.2          hsa-miR-9-5p  C1orf56      downregulated
#> hsa.miR.9.5p.3          hsa-miR-9-5p   DCBLD2      downregulated
#> hsa.miR.9.5p.9          hsa-miR-9-5p   MTHFD2      downregulated
#> hsa.miR.9.5p.12         hsa-miR-9-5p     SIX5      downregulated
#> hsa.miR.96.5p.1        hsa-miR-96-5p ARHGAP24        upregulated
#> hsa.miR.96.5p.2        hsa-miR-96-5p     BCL2        upregulated
#> hsa.miR.96.5p.3        hsa-miR-96-5p     CAV1        upregulated
#> hsa.miR.96.5p.5        hsa-miR-96-5p      DEK        upregulated
#> hsa.miR.96.5p.8        hsa-miR-96-5p      EZR        upregulated
#> hsa.miR.96.5p.9        hsa-miR-96-5p     FHL1        upregulated
#> hsa.miR.96.5p.15       hsa-miR-96-5p   MED12L        upregulated
#> hsa.miR.96.5p.18       hsa-miR-96-5p     SDC2        upregulated
#> hsa.miR.96.5p.19       hsa-miR-96-5p  SLC26A4        upregulated
#> hsa.miR.96.5p.20       hsa-miR-96-5p    SYNE2        upregulated
#>                     Corr.Coefficient Corr.P.Value Corr.Adjusted.P.Val
#> hsa.miR.1179.7            -0.8617647 8.902592e-06        6.579303e-04
#> hsa.miR.1179.10           -0.7764706 2.021754e-04        3.484055e-03
#> hsa.miR.1179.12           -0.7117647 9.920216e-04        7.248522e-03
#> hsa.miR.1179.14           -0.5970588 7.304866e-03        2.668766e-02
#> hsa.miR.1275.1            -0.7794118 1.858401e-04        3.484055e-03
#> hsa.miR.1275.2            -0.8382353 2.505171e-05        1.342354e-03
#> hsa.miR.1275.7            -0.5647059 1.133160e-02        3.755784e-02
#> hsa.miR.1275.8            -0.6676471 2.355991e-03        1.165309e-02
#> hsa.miR.1275.9            -0.6823529 1.793985e-03        9.944246e-03
#> hsa.miR.1275.10           -0.7264706 7.180913e-04        5.996529e-03
#> hsa.miR.1275.11           -0.6705882 2.233604e-03        1.130872e-02
#> hsa.miR.1275.14           -0.5735294 1.009552e-02        3.490010e-02
#> hsa.miR.1275.16           -0.6852941 1.695781e-03        9.649443e-03
#> hsa.miR.138.1.3p          -0.6235294 4.927825e-03        2.044253e-02
#> hsa.miR.138.1.3p.1        -0.8941176 1.505655e-06        2.420340e-04
#> hsa.miR.138.1.3p.8        -0.5529412 1.315725e-02        4.147114e-02
#> hsa.miR.138.1.3p.11       -0.7764706 2.021754e-04        3.484055e-03
#> hsa.miR.138.1.3p.14       -0.5676471 1.090730e-02        3.691259e-02
#> hsa.miR.138.5p.1          -0.5647059 1.133160e-02        3.755784e-02
#> hsa.miR.138.5p.2          -0.7176471 8.737675e-04        6.688482e-03
#> hsa.miR.138.5p.3          -0.7029412 1.193476e-03        7.993805e-03
#> hsa.miR.138.5p.7          -0.7441176 4.741414e-04        4.917305e-03
#> hsa.miR.138.5p.9          -0.7705882 2.384112e-04        3.484055e-03
#> hsa.miR.138.5p.11         -0.5970588 7.304866e-03        2.668766e-02
#> hsa.miR.138.5p.14         -0.6735294 2.116370e-03        1.080020e-02
#> hsa.miR.139.5p.3          -0.5588235 1.221826e-02        3.967848e-02
#> hsa.miR.139.5p.5          -0.6205882 5.156758e-03        2.046787e-02
#> hsa.miR.139.5p.6          -0.6970588 1.345295e-03        8.317543e-03
#> hsa.miR.139.5p.8          -0.6794118 1.896716e-03        1.042383e-02
#> hsa.miR.139.5p.15         -0.5705882 1.049535e-02        3.608828e-02
#> hsa.miR.139.5p.17         -0.5411765 1.520011e-02        4.654129e-02
#> hsa.miR.144.3p.4          -0.6852941 1.695781e-03        9.649443e-03
#> hsa.miR.144.3p.26         -0.6147059 5.639737e-03        2.184549e-02
#> hsa.miR.144.5p.7          -0.7058824 1.122950e-03        7.934693e-03
#> hsa.miR.146b.3p.1         -0.8294118 3.544227e-05        1.498483e-03
#> hsa.miR.146b.3p.9         -0.6823529 1.793985e-03        9.944246e-03
#> hsa.miR.146b.3p.10        -0.6911765 1.512359e-03        8.840428e-03
#> hsa.miR.146b.3p.11        -0.6470588 3.371039e-03        1.548270e-02
#> hsa.miR.146b.3p.13        -0.6764706 2.004126e-03        1.047685e-02
#> hsa.miR.146b.3p.15        -0.8264706 3.961774e-05        1.498483e-03
#> hsa.miR.146b.3p.16        -0.8500000 1.526130e-05        8.920924e-04
#> hsa.miR.146b.3p.17        -0.6205882 5.156758e-03        2.046787e-02
#> hsa.miR.146b.3p.22        -0.5911765 7.937790e-03        2.835555e-02
#> hsa.miR.146b.3p.23        -0.7264706 7.180913e-04        5.996529e-03
#> hsa.miR.146b.5p           -0.8235294 4.419570e-05        1.578769e-03
#> hsa.miR.146b.5p.2         -0.7117647 9.920216e-04        7.248522e-03
#> hsa.miR.146b.5p.3         -0.6852941 1.695781e-03        9.649443e-03
#> hsa.miR.146b.5p.4         -0.8029412 9.025840e-05        2.418173e-03
#> hsa.miR.146b.5p.5         -0.7029412 1.193476e-03        7.993805e-03
#> hsa.miR.146b.5p.6         -0.5382353 1.574661e-02        4.775978e-02
#> hsa.miR.146b.5p.7         -0.5529412 1.315725e-02        4.147114e-02
#> hsa.miR.146b.5p.8         -0.7176471 8.737675e-04        6.688482e-03
#> hsa.miR.146b.5p.10        -0.8264706 3.961774e-05        1.498483e-03
#> hsa.miR.146b.5p.15        -0.7117647 9.920216e-04        7.248522e-03
#> hsa.miR.146b.5p.16        -0.5352941 1.630793e-02        4.877209e-02
#> hsa.miR.146b.5p.17        -0.8352941 2.818566e-05        1.394106e-03
#> hsa.miR.146b.5p.18        -0.6176471 5.393992e-03        2.114840e-02
#> hsa.miR.182.5p            -0.8323529 3.164062e-05        1.453209e-03
#> hsa.miR.182.5p.2          -0.6676471 2.355991e-03        1.165309e-02
#> hsa.miR.182.5p.3          -0.6205882 5.156758e-03        2.046787e-02
#> hsa.miR.182.5p.4          -0.6411765 3.717210e-03        1.671445e-02
#> hsa.miR.182.5p.8          -0.5617647 1.176851e-02        3.860791e-02
#> hsa.miR.182.5p.10         -0.5352941 1.630793e-02        4.877209e-02
#> hsa.miR.182.5p.12         -0.7205882 8.190956e-04        6.502203e-03
#> hsa.miR.183.5p.6          -0.5882353 8.269861e-03        2.921715e-02
#> hsa.miR.183.5p.7          -0.6294118 4.494045e-03        1.939376e-02
#> hsa.miR.183.5p.11         -0.6823529 1.793985e-03        9.944246e-03
#> hsa.miR.204.5p.1          -0.8852941 2.573574e-06        3.266236e-04
#> hsa.miR.204.5p.2          -0.8088235 7.423780e-05        2.273091e-03
#> hsa.miR.204.5p.3          -0.7588235 3.270151e-04        4.043668e-03
#> hsa.miR.204.5p.8          -0.5941176 7.616200e-03        2.751245e-02
#> hsa.miR.204.5p.10         -0.9029412 8.388622e-07        2.420340e-04
#> hsa.miR.204.5p.11         -0.7205882 8.190956e-04        6.502203e-03
#> hsa.miR.204.5p.13         -0.8205882 4.920635e-05        1.665247e-03
#> hsa.miR.204.5p.14         -0.7205882 8.190956e-04        6.502203e-03
#> hsa.miR.21.3p             -0.6617647 2.616877e-03        1.265152e-02
#> hsa.miR.21.3p.1           -0.7558824 3.529453e-04        4.281959e-03
#> hsa.miR.21.3p.2           -0.7647059 2.798381e-04        3.911651e-03
#> hsa.miR.21.3p.3           -0.5911765 7.937790e-03        2.835555e-02
#> hsa.miR.21.3p.7           -0.8617647 8.902592e-06        6.579303e-04
#> hsa.miR.21.3p.8           -0.6764706 2.004126e-03        1.047685e-02
#> hsa.miR.21.5p             -0.7882353 1.432328e-04        3.076035e-03
#> hsa.miR.21.5p.1           -0.7970588 1.090490e-04        2.696867e-03
#> hsa.miR.21.5p.3           -0.7705882 2.384112e-04        3.484055e-03
#> hsa.miR.21.5p.4           -0.7882353 1.432328e-04        3.076035e-03
#> hsa.miR.21.5p.5           -0.7705882 2.384112e-04        3.484055e-03
#> hsa.miR.21.5p.6           -0.6764706 2.004126e-03        1.047685e-02
#> hsa.miR.21.5p.8           -0.9352941 5.360084e-08        3.446534e-05
#> hsa.miR.21.5p.10          -0.7323529 6.274791e-04        5.682663e-03
#> hsa.miR.21.5p.15          -0.7617647 3.026714e-04        4.043668e-03
#> hsa.miR.2110.1            -0.7705882 2.384112e-04        3.484055e-03
#> hsa.miR.2110.3            -0.6941176 1.426853e-03        8.574453e-03
#> hsa.miR.2110.9            -0.7823529 1.706104e-04        3.324317e-03
#> hsa.miR.2110.12           -0.6647059 2.483693e-03        1.209860e-02
#> hsa.miR.221.3p            -0.6411765 3.717210e-03        1.671445e-02
#> hsa.miR.221.3p.2          -0.6970588 1.345295e-03        8.317543e-03
#> hsa.miR.221.3p.3          -0.7441176 4.741414e-04        4.917305e-03
#> hsa.miR.221.3p.6          -0.7617647 3.026714e-04        4.043668e-03
#> hsa.miR.221.3p.17         -0.7382353 5.464254e-04        5.323508e-03
#> hsa.miR.221.3p.18         -0.5500000 1.364699e-02        4.239136e-02
#> hsa.miR.221.3p.21         -0.7382353 5.464254e-04        5.323508e-03
#> hsa.miR.221.5p            -0.5970588 7.304866e-03        2.668766e-02
#> hsa.miR.221.5p.1          -0.6911765 1.512359e-03        8.840428e-03
#> hsa.miR.221.5p.6          -0.7264706 7.180913e-04        5.996529e-03
#> hsa.miR.221.5p.7          -0.7941176 1.195955e-04        2.848144e-03
#> hsa.miR.221.5p.10         -0.6970588 1.345295e-03        8.317543e-03
#> hsa.miR.222.3p            -0.6323529 4.288792e-03        1.863306e-02
#> hsa.miR.222.3p.2          -0.7000000 1.267547e-03        8.316662e-03
#> hsa.miR.222.3p.4          -0.7058824 1.122950e-03        7.934693e-03
#> hsa.miR.222.3p.5          -0.7411765 5.092348e-04        5.197428e-03
#> hsa.miR.222.3p.9          -0.6970588 1.345295e-03        8.317543e-03
#> hsa.miR.222.3p.11         -0.5500000 1.364699e-02        4.239136e-02
#> hsa.miR.222.3p.18         -0.7323529 6.274791e-04        5.682663e-03
#> hsa.miR.222.3p.22         -0.7176471 8.737675e-04        6.688482e-03
#> hsa.miR.31.3p             -0.5382353 1.574661e-02        4.775978e-02
#> hsa.miR.31.3p.1           -0.5676471 1.090730e-02        3.691259e-02
#> hsa.miR.31.3p.2           -0.6235294 4.927825e-03        2.044253e-02
#> hsa.miR.31.3p.3           -0.6558824 2.900368e-03        1.381435e-02
#> hsa.miR.31.3p.4           -0.6500000 3.207853e-03        1.505584e-02
#> hsa.miR.31.3p.6           -0.6941176 1.426853e-03        8.574453e-03
#> hsa.miR.31.3p.7           -0.5558824 1.268109e-02        4.056686e-02
#> hsa.miR.31.5p.2           -0.6088235 6.157602e-03        2.342803e-02
#> hsa.miR.31.5p.5           -0.6029412 6.712063e-03        2.523893e-02
#> hsa.miR.31.5p.6           -0.6470588 3.371039e-03        1.548270e-02
#> hsa.miR.31.5p.7           -0.6764706 2.004126e-03        1.047685e-02
#> hsa.miR.31.5p.10          -0.7294118 6.715393e-04        5.915066e-03
#> hsa.miR.34a.5p            -0.7970588 1.090490e-04        2.696867e-03
#> hsa.miR.34a.5p.1          -0.8588235 1.023220e-05        6.579303e-04
#> hsa.miR.34a.5p.3          -0.5529412 1.315725e-02        4.147114e-02
#> hsa.miR.34a.5p.7          -0.5941176 7.616200e-03        2.751245e-02
#> hsa.miR.34a.5p.9          -0.6235294 4.927825e-03        2.044253e-02
#> hsa.miR.34a.5p.13         -0.6911765 1.512359e-03        8.840428e-03
#> hsa.miR.34a.5p.14         -0.6264706 4.706989e-03        1.991180e-02
#> hsa.miR.34a.5p.18         -0.6205882 5.156758e-03        2.046787e-02
#> hsa.miR.3613.5p.3         -0.8823529 3.047810e-06        3.266236e-04
#> hsa.miR.3613.5p.4         -0.7823529 1.706104e-04        3.324317e-03
#> hsa.miR.3613.5p.5         -0.6970588 1.345295e-03        8.317543e-03
#> hsa.miR.3613.5p.6         -0.6941176 1.426853e-03        8.574453e-03
#> hsa.miR.3613.5p.7         -0.5647059 1.133160e-02        3.755784e-02
#> hsa.miR.375.1             -0.5617647 1.176851e-02        3.860791e-02
#> hsa.miR.375.3             -0.7323529 6.274791e-04        5.682663e-03
#> hsa.miR.451a.2            -0.8088235 7.423780e-05        2.273091e-03
#> hsa.miR.451a.3            -0.6676471 2.355991e-03        1.165309e-02
#> hsa.miR.451a.7            -0.6117647 5.894203e-03        2.269444e-02
#> hsa.miR.486.3p.3          -0.5588235 1.221826e-02        3.967848e-02
#> hsa.miR.486.3p.5          -0.6735294 2.116370e-03        1.080020e-02
#> hsa.miR.486.3p.9          -0.7088235 1.055841e-03        7.628152e-03
#> hsa.miR.486.5p            -0.6323529 4.288792e-03        1.863306e-02
#> hsa.miR.486.5p.5          -0.5676471 1.090730e-02        3.691259e-02
#> hsa.miR.504.5p.6          -0.7588235 3.270151e-04        4.043668e-03
#> hsa.miR.504.5p.7          -0.5441176 1.466817e-02        4.534439e-02
#> hsa.miR.504.5p.9          -0.5852941 8.612643e-03        3.026191e-02
#> hsa.miR.504.5p.10         -0.6264706 4.706989e-03        1.991180e-02
#> hsa.miR.504.5p.11         -0.5970588 7.304866e-03        2.668766e-02
#> hsa.miR.551b.3p           -0.7382353 5.464254e-04        5.323508e-03
#> hsa.miR.551b.3p.3         -0.5735294 1.009552e-02        3.490010e-02
#> hsa.miR.551b.3p.4         -0.8588235 1.023220e-05        6.579303e-04
#> hsa.miR.551b.3p.8         -0.7000000 1.267547e-03        8.316662e-03
#> hsa.miR.551b.3p.10        -0.7235294 7.672406e-04        6.324817e-03
#> hsa.miR.551b.3p.12        -0.7881698 1.435164e-04        3.076035e-03
#> hsa.miR.551b.3p.13        -0.7705882 2.384112e-04        3.484055e-03
#> hsa.miR.551b.3p.14        -0.7676471 2.584418e-04        3.692846e-03
#> hsa.miR.577               -0.6352941 4.091032e-03        1.814161e-02
#> hsa.miR.577.4             -0.6470588 3.371039e-03        1.548270e-02
#> hsa.miR.577.8             -0.6764706 2.004126e-03        1.047685e-02
#> hsa.miR.577.9             -0.7029412 1.193476e-03        7.993805e-03
#> hsa.miR.577.10            -0.5500000 1.364699e-02        4.239136e-02
#> hsa.miR.577.17            -0.6558824 2.900368e-03        1.381435e-02
#> hsa.miR.652.3p.4          -0.8058824 8.192333e-05        2.394396e-03
#> hsa.miR.652.3p.6          -0.6500000 3.207853e-03        1.505584e-02
#> hsa.miR.652.3p.11         -0.7264706 7.180913e-04        5.996529e-03
#> hsa.miR.652.3p.12         -0.7117647 9.920216e-04        7.248522e-03
#> hsa.miR.652.3p.13         -0.7441176 4.741414e-04        4.917305e-03
#> hsa.miR.652.3p.18         -0.6147059 5.639737e-03        2.184549e-02
#> hsa.miR.652.3p.20         -0.6411765 3.717210e-03        1.671445e-02
#> hsa.miR.653.5p.1          -0.7470588 4.410535e-04        4.889610e-03
#> hsa.miR.653.5p.3          -0.6205882 5.156758e-03        2.046787e-02
#> hsa.miR.653.5p.6          -0.6323529 4.288792e-03        1.863306e-02
#> hsa.miR.653.5p.10         -0.7588235 3.270151e-04        4.043668e-03
#> hsa.miR.653.5p.12         -0.6647059 2.483693e-03        1.209860e-02
#> hsa.miR.653.5p.15         -0.6764706 2.004126e-03        1.047685e-02
#> hsa.miR.653.5p.21         -0.5352941 1.630793e-02        4.877209e-02
#> hsa.miR.653.5p.22         -0.6205882 5.156758e-03        2.046787e-02
#> hsa.miR.6842.3p.4         -0.7441176 4.741414e-04        4.917305e-03
#> hsa.miR.6842.3p.7         -0.5411765 1.520011e-02        4.654129e-02
#> hsa.miR.7.5p.6            -0.6735294 2.116370e-03        1.080020e-02
#> hsa.miR.873.3p            -0.8970588 1.246188e-06        2.420340e-04
#> hsa.miR.873.3p.1          -0.7323529 6.274791e-04        5.682663e-03
#> hsa.miR.873.3p.7          -0.7852941 1.564270e-04        3.244598e-03
#> hsa.miR.873.3p.10         -0.7352941 5.858078e-04        5.622006e-03
#> hsa.miR.873.3p.12         -0.6176471 5.393992e-03        2.114840e-02
#> hsa.miR.873.5p.1          -0.7294118 6.715393e-04        5.915066e-03
#> hsa.miR.873.5p.7          -0.7470588 4.410535e-04        4.889610e-03
#> hsa.miR.873.5p.11         -0.7705882 2.384112e-04        3.484055e-03
#> hsa.miR.874.3p.5          -0.7500000 4.098820e-04        4.880632e-03
#> hsa.miR.874.3p.6          -0.7764706 2.021754e-04        3.484055e-03
#> hsa.miR.874.3p.7          -0.5558824 1.268109e-02        4.056686e-02
#> hsa.miR.874.3p.11         -0.5558824 1.268109e-02        4.056686e-02
#> hsa.miR.874.3p.15         -0.7470588 4.410535e-04        4.889610e-03
#> hsa.miR.874.3p.16         -0.6088235 6.157602e-03        2.342803e-02
#> hsa.miR.874.3p.17         -0.7705882 2.384112e-04        3.484055e-03
#> hsa.miR.9.5p.2            -0.7029412 1.193476e-03        7.993805e-03
#> hsa.miR.9.5p.3            -0.5647059 1.133160e-02        3.755784e-02
#> hsa.miR.9.5p.9            -0.6205882 5.156758e-03        2.046787e-02
#> hsa.miR.9.5p.12           -0.7470588 4.410535e-04        4.889610e-03
#> hsa.miR.96.5p.1           -0.6058824 6.430149e-03        2.432109e-02
#> hsa.miR.96.5p.2           -0.8029412 9.025840e-05        2.418173e-03
#> hsa.miR.96.5p.3           -0.6264706 4.706989e-03        1.991180e-02
#> hsa.miR.96.5p.5           -0.7588235 3.270151e-04        4.043668e-03
#> hsa.miR.96.5p.8           -0.7029412 1.193476e-03        7.993805e-03
#> hsa.miR.96.5p.9           -0.6970588 1.345295e-03        8.317543e-03
#> hsa.miR.96.5p.15          -0.6352941 4.091032e-03        1.814161e-02
#> hsa.miR.96.5p.18          -0.5882353 8.269861e-03        2.921715e-02
#> hsa.miR.96.5p.19          -0.6000000 7.003561e-03        2.618192e-02
#> hsa.miR.96.5p.20          -0.5823529 8.966367e-03        3.133355e-02